A Quantitative Model of Calcium and Phosphate Metabolism

[+] Author and Article Information
E. B. Reeve, K. A. Joiner

Division of Laboratory Medicine, University of Colorado Medical Center, Denver, Colo.

J. Dyn. Sys., Meas., Control 95(3), 279-284 (Sep 01, 1973) (6 pages) doi:10.1115/1.3426715 History: Received May 16, 1973; Online July 13, 2010


Equations are given which describe elementary features of the absorption, distribution, and excretion of calcium and phosphate in man. Vitamin and hormonal regulation is primarily of calcium absorption from the gut, calcium entry into and loss from bone and renal excretion of calcium and phosphate. Phosphate entry into and release from bone is determined by stoichiometric relations with calcium, while a high and a low extracellular Ca × P “solubility product” determine calcium phosphate precipitation in the extraosseous tissues and failure of bone calcification, respectively. The results of infusion experiments in man are compared with model predictions.

Copyright © 1973 by ASME
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