Digital Simulation of the Chemical Control of Ventilation

[+] Author and Article Information
H. T. Milhorn, W. J. Reynolds

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Miss.

J. Dyn. Sys., Meas., Control 95(3), 335-339 (Sep 01, 1973) (5 pages) doi:10.1115/1.3426727 History: Received June 29, 1973; Online July 13, 2010


Experimental human data, obtained for the development and evaluation of a digital computer model of the human respiratory system, are presented. The data are from two series of experiments. In the first series the transient responses of tidal volume, respiratory frequency, minute ventilation, alveolar Pco2 and alveolar Po2 were obtained for several inspired CO2 concentrations (3, 5, 6, and 7 percent). In the second series, transient responses of the same variables were obtained for steps of inspired O2 concentration from room air to several lower oxygen levels (9, 8, and 7 percent). An example of the use of the data for the development and evaluation of a model is indicated.

Copyright © 1973 by ASME
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