Safe and reliable automatic pressure regulation of the oxygen mask is a primary consideration for the oxygen supply system. One kind of electronic oxygen regulator (EOR) structure is proposed, and its operation principle is explained in this paper. To avoid long controller design cycle, herein, some simulations are carried out on matlab for analysis by establishing a mathematical model according to the EOR flow dynamic characteristics. In the simulations, the all-coefficient adaptive control method based on a characteristic model (CM) and the proportional–integral–derivative (PID) algorithm are applied, and the results are thoroughly investigated by considering some disturbance, such as the user's changing pulmonary ventilation parameters, the air leakage of the mask, and the sensor noise. Results suggest that the all-coefficient control method is more effective to guarantee superior lower inspiratory resistance than the PID method with the environmental disturbance, which may be a plausible reference for the EOR controller design.