Medical devices and sensors are routinely used to record various physiological signals for simple monitoring of the human health, and sensing is an integral part of health monitoring. However, more advanced devices, signal measurement, modeling, and closed-loop control may be critical for surgical procedures, earlier diagnosis of diseases and disorders, drug administration, and clinical rehabilitation. The goal of this special issue is to provide a forum for latest research in biomedical signal measurement and processing, dynamic modeling and analysis, and control for clinical diagnosis, patient health monitoring, drug administration, and biosignal-assisted rehabilitation. There has been a significant increase in research activities in these areas within diverse specialties including mechanical, electrical, and biomedical engineering. Developing sensors to produce appropriate biosignals, developing dynamic models of biosystems and biosignals for diagnostics, and using biosignals as feedback in controlled processes such as drug delivery and rehabilitation are some of the biggest challenges encountered in these engineering fields.